Spatial transcriptomics identifies novel P. aeruginosa virulence factors
We used spatial transcriptomics to map the battlefield between Pseudomonas aeruginosa and host tissues during eye infections. By pinpointing where bacterial and host genes are active, we discovered a new virulence factor, PA2590, which plays a crucial role in infection. Our findings highlight the dynamic interplay between pathogens and hosts, offering new targets for combating bacterial infections!