Protein-Protein Interaction

In our study, we explored the gut microbiome across several autoimmune diseases, focusing particularly on systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD). We found that these two conditions share a strikingly similar set of microbial signatures distinct from other autoimmune disorders. These microbes may affect critical immune pathways, such as glucocorticoid signaling and interleukin-12, potentially disrupting the body’s natural immune response and fueling disease progression. By analyzing metagenomic data, we revealed that certain bacteria may interact with host proteins, which could influence immune system function!

We delved into the intricate dance between host and microbiome proteins to uncover disease-relevant pathways. By mapping interactions between human and bacterial proteins, we identified key connections that could illuminate the roles of gut microbes in conditions like IBD, colorectal cancer, obesity, and diabetes. Our findings offer exciting possibilities for targeting these interactions to improve health outcomes and shed light on the hidden mechanisms of microbiome-related diseases!